Activation of neuronal 5-HT1A receptors causes hyperpolarization and inhibition of cellular signaling.
Technically the answer is no, but subjective experiences may vary.
The 5-HT2A receptor is central to the effects of many psychedelics, but it may not be the only receptor involved.
It is a plant that contains over 40 alkaloid and non-alkaloid compounds, some of which have analgesic and psychoactive properties.
Ibogaine is a compound found in the leaves of an African shrub called Iboga, and studies indicate it may have anti-addictive properties.
Psychedelics disrupt the brain networks responsible for the feeling of selfhood.
Female hormones affect binding at the 5-HT2A receptor. Does this mean there is a uniquely female entourage effect with psychedelics?
Yes, and it may work via 5-HT2A as well as the cannabinoid receptors.
This is the first time psilocybin has been produced from a prokaryotic organism.
The evidence points to several possibilities. It could be psilocybin or a combination of factors.