Harmol

Harmol is a ß-carboline alkaloid compound present in fruits, herbs, spices, and sea-buckthorn berries.1 It was recently isolated from several species of mushrooms in the genus Psilocybe.2 Harmol is the main metabolite of harmine in humans.3 In some plant species such as Peganum harmala, harmol is found most abundantly in the roots.4

    References
  1. Harmol (HMDB0034217). Human Metabolome Database. http://www.hmdb.ca/metabolites/HMDB0034217.
  2. Blei F, Dörner S, Fricke J, et al. Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in “Magic” Mushrooms. Chemistry – A European Journal. 2019. doi:10.1002/chem.201904363
  3. Riba J, McIlhenny EH, Valle M, Bouso JC, Barker SA. Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca. Drug Testing and Analysis. 2012;4(7-8):610-616. doi:10.1002/dta.1344
  4. Herraiz T, González D, Ancín-Azpilicueta C, Arán VJ, Guillén H. beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food Chem Toxicol. 2010;48(3):839-845. doi:10.1016/j.fct.2009.12.019