Psychedelic trips often unfold without issues, but what if a trip needs to be stopped? Drugs such as benzodiazepines and antipsychotics are recommended as rescue medications and have been around for decades. Can ketanserin be used as a more targeted trip stopper?
Psychedelic drugs like psilocybin and LSD have been investigated for their anti-anxiety (anxiolytic) potential in people with end-of-life anxiety associated with severe illness, but the anxiolytic effects of LSD-assisted therapy had not yet been assessed in patients with anxiety disorders without life-threatening illness.
Despite excessive fear surrounding anecdotal reports of psychedelics inducing suicidal behaviors dating back to the 1950s, the current scientific landscape suggests potential therapeutic utility.
What is known about the divergent roles of the microscopic targets within the cardiovascular system and the cardiac risks versus benefits of psychedelics?
Psilocybin demonstrated preliminary efficacy for alcohol use disorder in a recent randomized clinical trial. The mechanism may lie in its interaction with glutamate receptors in the reward pathway of the brain.
Dr. Alex Kwan shares his insight on the field of preclinical psychedelic research and where he thinks things are headed in the future - in his lab, in drug discovery, and beyond.
Entactogenic drugs like MDMA and psychedelics like psilocybin may be beneficial for a range of psychiatric disorders. Though the pharmacology and subjective effects of entactogens and psychedelics differ, drugs that display qualities of both have received little attention to date.
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