Opening the Mushroom Pharmacopeia: The Case of Norbaeocystin
By engineering E. coli to produce norbaeocystin, researchers seek to settle whether this precursor to psilocybin is itself psychedelic.
Biology
The Doors of Expression: LSD Alters Epigenetics and Protein Induction
Psychedelics have demonstrated the potential for rapid, dramatic, and enduring therapeutic effects in people with psychiatric disorders as well as in animal models of these conditions. However, the molecular adaptations in the brain that underlie these profound psychedelic-induced behavioral changes have yet to be defined.
Exploring Ketamine’s Antimicrobial Effects & Fungal Sources: Part 2
As science unravels ketamine’s mechanisms of action to better understand its efficacy as an antidepressant, its antibacterial activity has been probed at the same time. Current research has found a naturally-occurring, fungal origin for the drug, exhibiting antiparasitic properties.
Exploring Ketamine’s Antimicrobial Effects & Fungal Sources: Part 1
As ketamine’s demonstrable therapeutic applications have become ever more popular, earlier research lauding its potential as an antimicrobial and antiparasitic agent has quietly reemerged.
Kambô: Another Psychedelic Amphibian?
Relatively unknown to Western medicine, Kambô is a frog skin secretion with potent, and potentially dangerous physiological and psychological effects.
MDMA-Assisted Psychotherapy for PTSD: Interviewing Dr. Rachel Yehuda
Dr. Rachel Yehuda shares details about an ongoing clinical trial involving MDMA-assisted psychotherapy to treat post-traumatic stress disorder in veterans.
Psychedelics and Substance Use Disorder: 4000 BCE to Present Day
The therapeutic uses of psychedelics were discovered over 6,000 years ago, but recent scientific exploration brings them to the mainstream.
Editor’s Choice Award 2021-Best Study on Psychedelics and Nature
The pace of psychedelic research continued its acceleration during 2021, culminating in several fascinating and groundbreaking studies. As the year comes to a close, Psychedelic Science Review is acknowledging some...
Editor’s Choice Award 2021-Best Study on Psychedelics and Neurochemistry
The pace of psychedelic research continued its acceleration during 2021, culminating in several fascinating and groundbreaking studies. As the year comes to a close, Psychedelic Science Review is acknowledging some...
Ibogaine and Cardiac Arrhythmia: The Heart of the Matter
Even at therapeutic doses, ibogaine may cause potentially life-threatening cardiac arrhythmia. Science is beginning to unravel the pharmacological factors that may underlie ibogaine-induced cardiotoxicity.