People tread lightly with this psychoactive species because it contains toxic compounds. But what benefits may be hidden inside?
Researchers suggest that the benefits of psychedelic treatment are mediated by a reduction in death anxiety and existential distress.
The serotonin 2A receptor is a major player in the psychedelic response, but it may not be the only one involved.
Despite differing pharmacodynamics, ketamine and serotonergic psychedelics may share downstream effects crucial to their rapid and sustained antidepressant activity.
This innovation may pave the way for pharmaceuticals that act like psychedelics at the 5-HT2A receptor but don’t have hallucinogenic effects.
These aren’t the truffles you’ll find in a restaurant, and they’re also quite distinct from psychedelic mushrooms.
The names may sound familiar, but these compounds reveal more about nature’s complex chemical cocktail in toad venom.
Ketamine and psilocybin both exert rapid antidepressant effects. Could these effects be explained by a common mechanism that promotes neurogenesis?
A recent study indicates that the empathogenic effects of LSD may be independent of serotonin 2A receptor activation.
The journey of psychedelics through the bloodstream and their interaction with the available serotonin receptors along the way.