Brain Morphology May Help Explain Differing Psilocybin Experiences
Understanding brain morphology differences may prove essential for creating effective psychedelic drug formulations.
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Hamilton Morris on 5-MeO-DMT, the Entourage Effect, and Protecting Toads
Morris has insightful ideas for studying psychedelic toad secretions while prioritizing the conservation of toads.
Habitat Influences Psychoactive Toad Secretions
Environment and diet may play a role in the alkaloid content of secretions from a Brazilian toad species.
New Biosynthesis of Psilocybin and Related Tryptamines
Researchers took the psilocybin-making genes from P. cubensis and put them into S. cerevisiae allowing them to produce psilocybin, several of its analogs, and a “new to nature” compound.
Psilocybin Superior to Ketamine for Prolonged Antidepressant-Like Effects (Rodent Model)
Results support the idea that serotonin 5-HT2A receptor-directed therapeutic strategies may be superior to ketamine-based treatments for depression.
Kratom Compound Mitragynine Reduces Neuropathic Pain, Study Finds
Pain was inhibited by an α2-adrenoceptor antagonist and reduced by an α1-adrenoceptor antagonist. Opioid receptors may also be involved in the effects.
Comparing Aeruginascin and Bufotenidine
Although aeruginascin is only present in psilocybin mushrooms and bufotenidine is present in toads, their structural and chemical similarities may be surprising.
G Protein-Coupled Receptors: What Are They and How Do They Work?
GPCRs play a major role in the psychedelic effect. They also have qualities that make them ideal targets for drug development.
Understanding Drug Potency and Its Importance in Psychedelic Research
Understanding the potency of the compounds in nature’s cocktails is essential for formulating effective doses.
The Structure and Function of the Serotonin 5-HT2B Receptor
Severe side effects associated with 5-HT2B agonist drugs have dampened the interest of researchers. The therapeutic potential of psychedelics provides incentive for taking it up again.