In the last 10 years, psychiatric interest in the use of psychedelics, such as psilocybin and LSD, has surged. A new study employed mice to examine how LSD could exert changes on the inflammatory response and the gut microbiome.
Allosteric modulation is a promising way to target the receptors of psychoactive substances, such as CB1R, for therapeutic use. However, it is difficult to design safe, effective allosteric compounds. New high-resolution structures of CB1R provide insight into a way forward for drug discovery.
The truth is that scientists don’t know enough about them. And research into any athletic-enhancing capabilities they may have is lacking.
How can genomics help with understanding and treating this condition?
THC binding to 5-HT2A may activate signaling pathways that cause negative effects on cognition and memory.
Stronger binding interactions between MDMB-Fubinaca and CB1 may explain why some synthetic cannabinoids cause dangerous effects.
Tetrahydrocannabiphorol could account for the pharmacological properties of some cannabis varieties which are difficult to explain by the presence of THC alone.
Yes, and it may work via 5-HT2A as well as the cannabinoid receptors.
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