Glutamate’s Role in Rapidly-Acting Antidepressants
Despite differing pharmacodynamics, ketamine and serotonergic psychedelics may share downstream effects crucial to their rapid and sustained antidepressant activity.
Scientific Studies
Glow Time: PsychLight Brings a Powerful Tool to Psychedelic Research
This innovation may pave the way for pharmaceuticals that act like psychedelics at the 5-HT2A receptor but don’t have hallucinogenic effects.
Scientists Isolate Two New Compounds from Toad Venom
The names may sound familiar, but these compounds reveal more about nature’s complex chemical cocktail in toad venom.
Same But Different: Antidepressant Mechanisms of Psilocybin and Ketamine
Ketamine and psilocybin both exert rapid antidepressant effects. Could these effects be explained by a common mechanism that promotes neurogenesis?
Exploring the Role of Serotonin 2A Activation in LSD’s Effects on Empathy
A recent study indicates that the empathogenic effects of LSD may be independent of serotonin 2A receptor activation.
Enzymes Responsible for DMT Synthesis Coexist in Mammalian Brain Cells
Is DMT produced in the brain? The answer remains unclear, but this 2019 study provides striking evidence supporting the neural-DMT synthesis hypothesis.
More Details on the Psilocybin Mushroom Bluing Reaction
Lenz et al. have revised their bluing theory based on the data from their new study.
Genetic Determinants of the LSD Response
Sensitive to LSD? It may be in your genes.
Psychedelics and Perception Part 1: The First Era of Research
Reviewing early research (1895-1975) on changes in visual perception.
Whole-Body Effects of Psychedelics – Part 1
How do psychedelics interact with the human body beyond brain cells?