Abuse Potential: Considerations for Rescheduling MDMA and Psychedelics
Can the meteoric rise of psychedelics and entactogens clear the legal hurdles of abuse potential assessment and rescheduling?
Industry
How To Stop A Psychedelic Trip: The Promise of Ketanserin
Psychedelic trips often unfold without issues, but what if a trip needs to be stopped? Drugs such as benzodiazepines and antipsychotics are recommended as rescue medications and have been around for decades. Can ketanserin be used as a more targeted trip stopper?
5-HT2A Virtual Chemical Screen Produces New Candidate Antidepressants
The serotonin receptor subtype 5-HT2A is key for the effects of many psychedelic substances in humans, but it is also a major drug target for new antidepressants. However, large challenges have prevented this therapeutic promise from being realised. Overcoming the early bottlenecks, innovative drug discovery methods have produced two new compounds with potential for therapeutic development.
Ecstasy for the 21st Century: Designer Drugs to Improve MDMA Therapy
The potential neurotoxicity of MDMA led to the development of APBs, a family of entactogens whose effect profiles may position them as attractive candidates for the next generation of entactogenic medicines.
COMPASS Patent Challenge Targets Crystallography Errors
Experts say COMPASS’ analysis overlooked one of the crystal forms present in their sample.
Myth Busting: Magic Mushroom Spores Have Little to do with Potency
False. Read on to find out how sporulation impacts the potency of Psilocybe cubensis.
The Psychedelic Entourage Effect: Part 6 – The State of the Art
Some scientists are skeptical of the entourage effect in psychedelics as research companies are charging ahead with the concept.
Catching Up with the Psychedelic Entourage Effect: Part 4 – CaaMTech
Patent filings indicate that CaaMTech was the first company to propose an entourage effect in psychedelic compounds.
Catching Up with the Psychedelic Entourage Effect: Part 3 – Field Trip Discovery
This company is approaching psychedelic mushroom research literally from the ground up.
Hamilton Morris Synthesizes 5-MeO-DMT in “Pharmacopeia”
“I believe one person can produce enough 5-MeO-DMT to supply everyone that would ever want it.”