Psychedelic trips often unfold without issues, but what if a trip needs to be stopped? Drugs such as benzodiazepines and antipsychotics are recommended as rescue medications and have been around for decades. Can ketanserin be used as a more targeted trip stopper?
Allosteric modulation is a promising way to target the receptors of psychoactive substances, such as CB1R, for therapeutic use. However, it is difficult to design safe, effective allosteric compounds. New high-resolution structures of CB1R provide insight into a way forward for drug discovery.
By engineering E. coli to produce norbaeocystin, researchers seek to settle whether this precursor to psilocybin is itself psychedelic.
Psychedelics may hold the key to a novel PTSD treatment.
Experts say COMPASS’ analysis overlooked one of the crystal forms present in their sample.
The therapeutic uses of psychedelics were discovered over 6,000 years ago, but recent scientific exploration brings them to the mainstream.
The pace of psychedelic research continued its acceleration during 2021, culminating in several fascinating and groundbreaking studies. As the year comes to a close, Psychedelic Science Review is acknowledging some...
Even at therapeutic doses, ibogaine may cause potentially life-threatening cardiac arrhythmia. Science is beginning to unravel the pharmacological factors that may underlie ibogaine-induced cardiotoxicity.
Although there are distinct differences between our species, the mouse serotonin 2A receptor plays a crucial role in human psychedelic drug research.
Scientists know there’s more to magic mushrooms than just psilocybin. But as the psychedelic industry begins taking shape, could the mushroom itself be left behind?