Psilocybin demonstrated preliminary efficacy for alcohol use disorder in a recent randomized clinical trial. The mechanism may lie in its interaction with glutamate receptors in the reward pathway of the brain.
Previous research in people with substance use disorders and animal models of drug addiction indicate that classical psychedelics like LSD and psilocybin may reduce drug use and drug-seeking behavior. However, the mechanism of action underlying the anti-addictive effects of psychedelics remains unknown.
The therapeutic uses of psychedelics were discovered over 6,000 years ago, but recent scientific exploration brings them to the mainstream.
18-MC is challenging standard anti-addiction treatments and brain research.
Comments from Matthew Johnson of Johns Hopkins provide an update on this research.
Recent evidence suggests psychedelics may significantly improve addiction treatment outcomes.
New research suggests that ketamine can aid in reorganizing alcohol-related memories.