Finding the Psychedelic Sweet Spot
The relationship between efficacy and potency is a key concept in understanding psychedelic drug pharmacology.
Neurochemistry
The Psychedelic Entourage Effect: Part 6 – The State of the Art
Some scientists are skeptical of the entourage effect in psychedelics as research companies are charging ahead with the concept.
The Effects of Antidepressant Discontinuation on MDMA-Assisted Psychotherapy
Recent antidepressant exposure may reduce the treatment efficacy of MDMA.
Catching Up With the Psychedelic Entourage Effect: Part 5 – MindMed
MindMed just started a Phase 1 trial which is studying the effects of LSD + MDMA administered together.
The Problem and Paradox of Bad Trips, Part 2
Transforming a bad trip often means giving it a place and purpose in one’s larger life story.
The Problem and Paradox of Bad Trips – Part 1
Bad trips look much different in psychedelic therapy than in uncontrolled settings.
The Nuances of Ketamine’s Neurochemistry
What's similar and different about the R and S isomers of ketamine?
The Structure-Activity Relationship of Psilocybin Analogs
Seventeen 4-acetoxy and 4-hydroxy substituted derivatives “have psilocybin-like pharmacological properties.”
‘Pharmacopeia’ Season Finale Features Cutting Edge Psychedelic Research
“We have some [compounds] now that are unlike anything you’ve ever seen before.”
The Role of Oxytocin in MDMA’s Prosocial Effects
The link between oxytocin and MDMA is less straightforward than once thought.