Understanding the potency of the compounds in nature’s cocktails is essential for formulating effective doses.
Severe side effects associated with 5-HT2B agonist drugs have dampened the interest of researchers. The therapeutic potential of psychedelics provides incentive for taking it up again.
Results hint at a possible mechanism for the persistent effect that psilocybin has on mindfulness.
Research is revealing that the psychedelic effect is due to much more than 5-HT2A activation.
Greater potency means doing more with less. But does norpsilocin even have a role in the psychedelic effect?
Baeocystin does not cause the head twitch in mice, but its metabolite norpsilocin is more potent than psilocin.
Yes, based on its effects. But it doesn’t work via the serotonin 5-HT2A receptor like other psychedelics.
Scientists Synthesize and Test the Magic Mushroom Compounds Baeocystin, Norbaeocystin, Norpsilocin, and Aeruginascin
This work is a giant step forward for psychedelic research.
Recent evidence suggests psychedelics may significantly improve addiction treatment outcomes.
Activation of neuronal 5-HT1A receptors causes hyperpolarization and inhibition of cellular signaling.