A default level of brain activity sheds light on the source of consciousness and mechanisms of ego death.
While ketamine produces a whole symphony of effects in the brain, surprisingly, a localized neural oscillation in a lesser-known area of the brain is enough to cause feelings of dissociation.
Research suggests that BDNF can help rewire and overwrite stubborn neural pathways by creating new connections that facilitate more flexible and adaptive thoughts and behaviours. Psychedelics appear to tap into this mechanism.
THC binding to 5-HT2A may activate signaling pathways that cause negative effects on cognition and memory.
"Now we know how psychedelic drugs work – finally! We might be able to switch some effects on while keeping others off."
Stronger binding interactions between MDMB-Fubinaca and CB1 may explain why some synthetic cannabinoids cause dangerous effects.
High-resolution structure reveals how LSD binds to and activates the canonical mind-altering receptor.
For humans, drug doses are based largely on body weight. But in animals, differences in brain and body chemistry make the calculations far more complicated.
The “psychedelic drug” label appears to define a clear-cut category. However, there are lesser-known research chemicals that depict more diffuse boundaries in this classification.
Researchers will examine whether MDMA can offset some of the negative side effects of LSD in a therapeutic setting.