Editor’s Choice Award – Best Psychedelic Chemistry/Synthesis Study of 2020
This study provides meaningful access to some lesser-known magic mushroom compounds and conducts biological testing on them for the first time.
Neurochemistry - Page 6
Methoxetamine: Cousin of Ketamine
The characterization of methoxetamine, a ketamine analog, and how its action on the serotonin system sets it apart.
Insights Into the Neurophysiology of Tryptamine-Derived Hallucinogens
Brain imaging research reveals where psychedelic compounds such as psilocybin and LSD manifest their effects.
It Takes Guts: Psychedelic Treatment Approaches to Autoimmune Disorders
There is much research into psychedelic treatment of mental disorders, but psychedelics might be effective in treating autoimmune disorders as well.
How to Change Your Ability to Change
The monoamine hypothesis of depression leaves many patients without effective help. It’s time for a paradigm shift, and psychedelics may be leading the way.
What is the Default Mode Network?
A default level of brain activity sheds light on the source of consciousness and mechanisms of ego death.
Ketamine-Induced Brain Rhythm Causes Dissociation: From Mice to Man
While ketamine produces a whole symphony of effects in the brain, surprisingly, a localized neural oscillation in a lesser-known area of the brain is enough to cause feelings of dissociation.
Food for Thought: Can Psychedelics Boost Brain Growth Factor Levels?
Research suggests that BDNF can help rewire and overwrite stubborn neural pathways by creating new connections that facilitate more flexible and adaptive thoughts and behaviours. Psychedelics appear to tap into this mechanism.
THC and the 5-HT2A Receptor: What’s Going On?
THC binding to 5-HT2A may activate signaling pathways that cause negative effects on cognition and memory.
Crystal Structure of LSD and 5-HT2AR Part 2: Binding Details and Future Psychedelic Research Paths
"Now we know how psychedelic drugs work – finally! We might be able to switch some effects on while keeping others off."