THC and the 5-HT2A Receptor: What’s Going On?
THC binding to 5-HT2A may activate signaling pathways that cause negative effects on cognition and memory.
Neurochemistry - Page 7
Crystal Structure of LSD and 5-HT2AR Part 2: Binding Details and Future Psychedelic Research Paths
"Now we know how psychedelic drugs work – finally! We might be able to switch some effects on while keeping others off."
Crystal Structure of CB1 and MDMB-Fubinaca Gives Insight Into Synthetic Cannabinoids’ Potency
Stronger binding interactions between MDMB-Fubinaca and CB1 may explain why some synthetic cannabinoids cause dangerous effects.
Crystal Structure of LSD and 5-HT2AR- Part 1: Capturing the First Steps of a Psychedelic Trip
High-resolution structure reveals how LSD binds to and activates the canonical mind-altering receptor.
Figuring Out a Mouse-Sized Dose of LSD
For humans, drug doses are based largely on body weight. But in animals, differences in brain and body chemistry make the calculations far more complicated.
Quipazine: A Long-Standing Enigma in Psychedelic Research
The “psychedelic drug” label appears to define a clear-cut category. However, there are lesser-known research chemicals that depict more diffuse boundaries in this classification.
MindMed and Liechti Lab to Conduct the First Clinical Trial Combining LSD and MDMA
Researchers will examine whether MDMA can offset some of the negative side effects of LSD in a therapeutic setting.
The Role of the Claustrum in the Psychedelic Experience
Brain scans show that psilocybin modulates claustrum connectivity in brain networks.
Examining the Cognitive Neuroscience of Psychedelics
The new REBUS model helps explain the subjective and neurochemical effects of psychedelics on the brain.
Study Finds Aeruginascin Metabolite 4-HO-TMT is Active at the Serotonin 5-HT2A Receptor
Surprisingly, 4-HO-TMT has binding affinity similar to psilocin at 5-HT2A.