Greater potency means doing more with less. But does norpsilocin even have a role in the psychedelic effect?
Baeocystin does not cause the head twitch in mice, but its metabolite norpsilocin is more potent than psilocin.
Yes, based on its effects. But it doesn’t work via the serotonin 5-HT2A receptor like other psychedelics.
Scientists Synthesize and Test the Magic Mushroom Compounds Baeocystin, Norbaeocystin, Norpsilocin, and Aeruginascin
This work is a giant step forward for psychedelic research.
Recent evidence suggests psychedelics may significantly improve addiction treatment outcomes.
Activation of neuronal 5-HT1A receptors causes hyperpolarization and inhibition of cellular signaling.
Even slightly modifying the chemical structure of the compounds in kratom can significantly alter their effects.
Technically the answer is no, but subjective experiences may vary.
The 5-HT2A receptor is central to the effects of many psychedelics, but it may not be the only receptor involved.
The authors argue that the serotonergic mediation of estrogen has important clinical implications and warrants further investigation.