Lab grown brains help to shed insight on 5-MeO-DMT mechanisms.
A recent study found that Single Nucleotide Polymorphisms (SNPs) in the 5-HT2AR gene may impact the effects of clinically relevant psychedelics. This research implies that patients carrying certain polymorphisms may respond differentially to psychedelic-assisted interventions, an important consideration for the design and interpretation of future clinical trials.
What is known about the divergent roles of the microscopic targets within the cardiovascular system and the cardiac risks versus benefits of psychedelics?
Entactogenic drugs like MDMA and psychedelics like psilocybin may be beneficial for a range of psychiatric disorders. Though the pharmacology and subjective effects of entactogens and psychedelics differ, drugs that display qualities of both have received little attention to date.
The potential use of serotonergic psychedelic drugs has yet to be explored for treatment of multimodal health issues such as obesity. A new preclinical study aims to explore the effects of psilocybin in rodent food consumption and weight gain.
Prior studies in clinical populations with OCD as well as animal models of this disorder indicate that psilocybin may suppress compulsive behavior. Although efforts to identify the mechanism of psilocybin’s effects are underway, the pharmacological targets underlying its anti-compulsive potential remain elusive.
Psychedelics have demonstrated the potential for rapid, dramatic, and enduring therapeutic effects in people with psychiatric disorders as well as in animal models of these conditions. However, the molecular adaptations in the brain that underlie these profound psychedelic-induced behavioral changes have yet to be defined.
Previous research in both people with OCD and animal models of the disorder indicate that psilocybin and related compounds may rapidly reduce compulsive behavior. However, the mechanism of action underlying the anti-compulsive effects of psilocybin remains unknown.
As science unravels ketamine’s mechanisms of action to better understand its efficacy as an antidepressant, its antibacterial activity has been probed at the same time. Current research has found a naturally-occurring, fungal origin for the drug, exhibiting antiparasitic properties.
As ketamine’s demonstrable therapeutic applications have become ever more popular, earlier research lauding its potential as an antimicrobial and antiparasitic agent has quietly reemerged.