Escalating LSD doses lead to more pronounced subjective and autonomic effects, while pre-administration of ketanserin prevents the effects of a high LSD dose.
While ketamine produces a whole symphony of effects in the brain, surprisingly, a localized neural oscillation in a lesser-known area of the brain is enough to cause feelings of dissociation.
Both have long-lasting positive effects on mood, social skills and neuroplasticity. Combining them may potentiate and prolong mutual therapeutic effects.
Research suggests that BDNF can help rewire and overwrite stubborn neural pathways by creating new connections that facilitate more flexible and adaptive thoughts and behaviours. Psychedelics appear to tap into this mechanism.
"Now we know how psychedelic drugs work – finally! We might be able to switch some effects on while keeping others off."
High-resolution structure reveals how LSD binds to and activates the canonical mind-altering receptor.