Perlolyrine is a member of the ß-carboline family of compounds.1 It is a naturally occurring metabolite found the mycelium of fungi. It was first isolated in 1988 from Codonopsis pilosula, a perennial flowering plant in the bellflower family Campanulaceae.2  Recently, researchers isolated perlolyrine from several species of psychedelic mushrooms in the genus Psilocybe.3

  1. Perlolyrine (CHEBI:69444). ChEBI - Chemical Entities of Biological Interest.
  2. Liu T, Liang W, Tu G. Perlolyrine: a β-carboline alkaloid from Codonopsis pilosula. Planta medica. 1988;54(05):472–473.
  3. Blei F, Dörner S, Fricke J, et al. Simultaneous Production of Psilocybin and a Cocktail of β-Carboline Monoamine Oxidase Inhibitors in “Magic” Mushrooms. Chemistry – A European Journal. 2019. doi:10.1002/chem.201904363