In March 2019, researchers at Johns Hopkins School of Medicine published a paper in The American Journal of Drug and Alcohol Abuse examining the improvements in anxiety and depression study participants experienced using 5-MeO-DMT (N, N-dimethyl-5-methoxytryptamine) in a naturalistic group setting. Eighty percent of those diagnosed with depression reported improvement in depressive symptoms. Of those diagnosed with anxiety, 79% reported improvement. The researchers also observed from the data that, “Improvement in depression/anxiety conditions were associated with greater intensity of mystical experiences and higher ratings of the spiritual significance and personal meaning of the 5-MeO-DMT experience.” Of particular interest when it comes to 5-MeO-DMT in therapeutic applications is its fast action and short duration compared to other psychedelics.