The Chemistry of 1P-LSD
The scientific literature contains little information about 1P-LSD. Its first date of synthesis is unknown, and mentions of it only start to appear in the psychonaut community around January 2015.1
1P-LSD is a derivative of LSD and a homolog of ALD-52. It belongs to the ergoline family of compounds, which includes LSD. The chemical structure of 1P-LSD differs from LSD by having a propanoyl group on the nitrogen atom in the indole ring.
The Pharmacology of 1P-LSD
A recent study found Ki values for 1P-LSD of 637 nM, 196 nM, and 13.0 nM, at serotonin 5-HT1A, 5-HT2A, and 5-HT2C, respectively.2 Receptor activity studies indicated that 1P-LSD is a very weak partial agonist at the human 5-HT2A receptor compared to LSD, but it did induce the head-twitch response in mice. However, 1P-LSD showed no agonist activity at 5-HT2A and 5-HT2C despite showing comparatively high affinity those receptors compared to LSD. Additional work indicated that 1B-LSD produced a dose-dependent increase in head twitches.3
The data from a November 2019 study indicates that 1P-LSD is a prodrug of LSD.2 High levels of LSD were found in the blood plasma of rats after they were administered 1P-LSD subcutaneously.
The Applications and Potential of 1P-LSD
As a prodrug of LSD, 1P-LSD may provide drug formulation options due to its different solubility and other physical properties.