UK researchers tested 12 people (6 men, 6 women) with moderate to severe treatment-resistant depression (TRD) with two oral doses of psilocybin (10 mg and 25 mg) 7 days apart. Psychological support was provided before, dosing, and after each dosing session. The psilocybin was well-tolerated there were no serious side effects. Depressive symptoms were markedly reduced one week and three months after the high dose treatment. There was also a significant improvement in anxiety and enjoyment of life.