This study found that the secretions of the Sonoran Desert toad, Bufo alvarius, are toxic when taken orally but can be safely dried and smoked. This is the first documentation of a hallucinogenic agent naturally occurring in the animal kingdom. From this, the authors propose the Precolumbian peoples of the New World may have used the psychoactive toad in their culture.
Weil and Davis Discover 5-MeO-DMT in Toad Secretions
The secretions of Bufo alvarius are toxic when taken orally but can be safely dried and smoked.