Europeans discover the Xochipilli Prince of Flowers statue which has carvings of Psilocybe.
Dr. Everard Brande of London, England is the first to document the effects of psychedelic mushrooms on humans in a medical journal.
Dr. William Heberden writes in the Gentleman's Magazine about the behavior of a family after eating mushrooms.
Florentine Codex is Published and Contains Description of Aztecs Using Peyote and Hallucinogenic Mushrooms
Spanish priest Bernardino de Sahagùn writes in the Florentine Codex about the Aztecs using peyote and hallucinogenic mushrooms.
Catholic priests punish native Mexicans for using entheogens.
Physician Pieter van Foreest describes the behavior of a woman after eating mushrooms.
The Codex Magliabecchiano is written and contains at least one illustration showing teonanacátl mushrooms.
The Mixtec Mesoamerican Codex shows the ritual use of mushrooms by Mixtec gods.
Chang Hua's "Record of Investigation of Things" (Po Wu Chih) describes what could be the use of hallucinogenic mushrooms during the Chin (Jin)Dynasty.
A mural in the Selva Pascuala cave near Villar del Humo, Spain depicts what researchers believe are Psilocybe hispanica mushrooms.
Cave art in Tassili n'Ajjer SE Algeria shows the oldest known petroglyphs of psychoactive mushrooms, specifically Psilocybe.