Researchers find 5-HT2 receptor subtypes in the brain are an important component of the hallucinatory action of LSD and other chemically similar hallucinogens.
Researchers find the total psilocybin and psilocin levels in 20 species hallucinogenic mushrooms from the Pacific Northwest US to range from 0.1% to nearly 2.0% by dry weight.
Study finds the levels of psilocybin and psilocin in Psilocybe cubensis grown under controlled conditions increase with repeated harvests of the fruiting bodies and are predictable compared to samples from uncontrolled outside sources.
Researchers synthesize baeocystin from 2-methyl-2-nitrophenol.
Researchers find baeocystin in three of 10 species of mushrooms from the US, Canada, Mexico, and Peru.
Researchers isolate and characterize baeocystin and norbaeocystin from Psilocybe baeocystis.
Researchers find psilocybin and psilocin sometimes act like serotonin but act against it at higher concentrations.
Study finds psilocybin and psilocin cause qualitative effects similar to mescaline, but that mescaline is longer lasting and less potent. The data also showed psilocin is more potent and shorter acting than psilocin.
Researchers study the effects mescaline and psilocybin have on spider web building.
The Good Friday Experiment finds that psilocybin can catalyze spiritual experiences in religious people.
Henri Michaux publishes a first-hand account of his experience taking "psilocybin prepared from Psilocybe mexicana."
The Harvard Psilocybin Project is founded by Timothy Leary and Richard Alpert.
Researchers at the US National Institute of Mental Health (NIMH) find psilocybin effects begin 10-15 minutes after oral ingestion and produce effects similar to LSD.
Albert Hofmann publishes the first synthesis of psilocybin.
French researchers obtained crystalline psilocybin and very small amounts of psilocin from both the spores and sclerotia of Psilocybe mexicana.
Albert Hofmann isolates psilocybin and psilocin from mushrooms.
The CIA starts Project MKUltra using human subjects to develop drugs and administration procedures to be used in interrogations.
Amateur mycologist Robert Gordon Wasson visits Oaxaca, Mexico and witnesses a mushroom velada.
This study may capture an early observation of the importance of the mystical experience in psychedelic therapy.
Richard Schultes publishes his thesis describing teonanacátl as a psilocybin mushroom.
Albert Hofmann synthesizes LSD-25 for the first time while working at Sandoz Laboratories in Switzerland.
Richard Schultes and Blas Pablo Reko collect psychoactive mushrooms from Mexico and take them to the herbarium at Harvard University.
Blas Pablo Reko confirms teonanacátl as a psilocybin mushroom, not peyote.
German chemist Richard Manske synthesizes DMT for the first time.
Ernst Spath is the first to synthesize mescaline.
Science magazine publishes a first-hand psilocybin experience written by a botanist calling himself "Mr. W."
American mycologist Franklin Sumner Earle is the first to collect Psilocybe cubensis in Cuba.
Dybowski and Landrin Isolate Ibogaine From Tabernanthe iboga