Pharma companies with expertise in 5-HT3 receptors are focusing on antagonist drugs to combat nausea and vomiting in chemotherapy patients.
Many factors are at play in creating the mysterious cocktail of psychoactive chemicals found in magic mushrooms.
The head-twitch response in rodents indicates stimulation of the 5-HT2A receptor. This knowledge helps researchers design experiments to understand how psychedelics work.
This is the first time researchers have correlated psilocin bound to 5-HT2A receptors in the brain, levels of psilocin in the blood, and subjective experiences.
Magic mushrooms may be synthesizing this newly-discovered compound from baeocystin.
Binding affinity studies show psilocin and psilocybin have different preferences for serotonin receptors.
You may have heard of magic mushrooms or even consumed them. But what are they?
Psilocybin produces more insightful and mystical experiences, but dextromethorphan causes greater feelings of disembodiment.
Data analysis and gene expression maps confirm the role of the 5-HT2A receptor in the effects of LSD.
Researchers push to move psilocybin from Schedule I to Schedule IV if Phase III clinical trials are successful.