4-HO-DPT is a synthetic compound that is not known to occur in nature. However, in 1990, mushroom researcher Jochen Gartz patented a method for adding DPT to mushroom growth medium which resulted in the mushroom fruiting bodies containing 4-HO-DPT.1

The Chemistry of 4-HO-DPT

4-HO-DPT is a psilocybin derivative and a structural homolog of psilocin. Repke et al. were first to report the synthesis of 4-HO-DPT  in 1977.2

In October 2019, researchers solved the crystal structure of 4-HO-DPT.3 They describe the structure as “…a singly protonated DPT cation, one half of a fumarate dianion (completed by a crystallographic centre of symmetry) and two water molecules of crystallization in the asymmetric unit.”

The Pharmacology of 4-HO-DPT

Little is known about the pharmacology of 4-HO-DPT. Alexander and Ann Shulgin documented their synthesis of 4-HO-DPT (#20 in TiHKAL), and describe a 20 mg oral dose as, “Possible threshold, nothing more.” 4

The new crystal structure of 4-HO-DPT discussed earlier opens to door to understanding its physical properties. This discovery also allows scientists to test its activity at biological receptors.

The Applications and Potential of 4-HO-DPT

Prior to the current work to solve its crystal structure, virtually nothing was known about 4-HO-DPT. Characterizing this fundamental structure is essential for all downstream research, such as structure-activity relationships that define the biological and clinical properties of the molecule. Understanding these relationships is key to developing effective drugs.