G Protein-Coupled Receptors: What Are They and How Do They Work?
GPCRs play a major role in the psychedelic effect. They also have qualities that make them ideal targets for drug development.
Articles by Barbara E. Bauer, MS
Understanding Drug Potency and Its Importance in Psychedelic Research
Understanding the potency of the compounds in nature’s cocktails is essential for formulating effective doses.
The Structure and Function of the Serotonin 5-HT2B Receptor
Severe side effects associated with 5-HT2B agonist drugs have dampened the interest of researchers. The therapeutic potential of psychedelics provides incentive for taking it up again.
Psilocybin Mindfulness Negatively Correlated with 5-HT2A Binding, Study Finds
Results hint at a possible mechanism for the persistent effect that psilocybin has on mindfulness.
Cellular Receptors and Their Role in the Psychedelic Effect
Research is revealing that the psychedelic effect is due to much more than 5-HT2A activation.
Study Shows Norpsilocin is More Potent Than Psilocin at 5-HT2A
Greater potency means doing more with less. But does norpsilocin even have a role in the psychedelic effect?
Scientists Solve Another Crystal Structure of the Psilocybin Analog Miprocin, 4-HO-MiPT
This is the second crystal structure of this compound, providing additional options for developing psychedelics into therapeutic drug formulations.
5 Fast Facts You May Not Know About Albert Hofmann and LSD
Hofmann’s work with LSD started with purpose, faded away, and then went down in history.
Study Indicates the Magic Mushroom Compound Baeocystin is Not Psychedelic
Baeocystin does not cause the head twitch in mice, but its metabolite norpsilocin is more potent than psilocin.
2020 State of the Art of Psychedelic Technology – Where Is It Heading?
In 2020, the path forward for psychedelic drug research goes in several directions.