To solve the crystal structure of LSD bound to the serotonin 5-HT2A receptor, structural biologists used cutting-edge, high-resolution imaging techniques such as cryo-EM, cryogenic electron microscopy. In an interview with Inverse, Dr. Bryan Roth of the University of North Carolina Chapel Hill School of Medicine said, “Now we know how psychedelic drugs work – finally!
First Crystal Structure of LSD on 5-HT2A Receptor
The discovery reported by Kim at al. in the journal Cell sheds light on how compounds interact with and activate this canonical receptor.