Study Finds Norpsilocin is More Potent Than Psilocin at 5-HT2A

This is the first scientific evidence that anything but psilocybin or psilocin could potentially contribute to the pharmacology of magic mushrooms.

February 2020

In a February 2020 study published in the Journal of Natural Products, Sherwood et al. describe their work synthesizing and studying four lesser-known magic mushroom (aka psilocybin mushroom) compounds; aeruginascinnorpsilocin, baeocystin, and norbaeocystin.1

The authors tested norpsilocin to see if it activated the serotonin 5-HT2A receptor by using a test that measures the Gq-mediated calcium flux at 5-HT2A. The data indicated that compared to psilocin, norpsilocin was almost a full agonist at the mouse and human 5-HT2A receptor. The authors stated,

Norpsilocin was thus as potent if not more efficacious compared to psilocin…