Scientists Solve the Crystal Structure of the Fumarate Salts of DMT and Psilocin Derivatives

The new crystalline fumarate salts of MiPT and 4-HO-MiPT could be used to modulate the effects of compounds in a drug formulation.

September 2019

Researchers have published the crystal structures of the fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin.1 These derivatives of DMT and psilocin are more commonly known as MiPT and 4-HO-MiPT, respectively.

The names of the compounds are N-isopropyl-N-methyltryptaminium (MiPT) fumarate and 4-hydroxy-N-isopropyl-N-methyltryptaminium (4-HO-MiPT) fumarate monohydrate.

The researchers describe the crystal structures by saying “Both salts possess a protonated tryptammonium cation and a 3-carboxyacrylate (hydrogen fumarate) anion in the asymmetric unit; the 4-HO-MiPT structure also contains a water molecule of crystallization.”

These fumarate salts present new chemistries for further research to understand their therapeutic potential.