Glutamate’s Role in Rapidly-Acting Antidepressants
Despite differing pharmacodynamics, ketamine and serotonergic psychedelics may share downstream effects crucial to their rapid and sustained antidepressant activity.
Mental Health - Page 4
Same But Different: Antidepressant Mechanisms of Psilocybin and Ketamine
Ketamine and psilocybin both exert rapid antidepressant effects. Could these effects be explained by a common mechanism that promotes neurogenesis?
Exploring the Role of Serotonin 2A Activation in LSD’s Effects on Empathy
A recent study indicates that the empathogenic effects of LSD may be independent of serotonin 2A receptor activation.
In Awe: Psychedelic Assisted Psychotherapy and the Mystical Experience
A fresh theoretical framework for understanding the role of awe in Psychedelic Assisted Psychotherapy.
Mouse Study Reveals New Details on Psilocybin’s Rewiring of the Brain
Changes in structural neuroplasticity start within 24 hours, are enduring, and may not be solely dependent on 5-HT2A.
Keeping Participants Safe in Psychedelic Research
Psychedelic science operates with an abundance of caution.
Active vs. Passive Coping Distinguishes Antidepressants and Psychedelics
5-HT1AR vs. 5-HT2AR signaling and the treatment of depression.
Genetic Determinants of the LSD Response
Sensitive to LSD? It may be in your genes.
Real-World Research in Psychedelic Science
Researchers see value in a naturalistic approach to psychedelic studies.
Psychedelic Treatment for Eating Disorder Recovery
Experts see a "mechanistic grounding" for testing psychedelics on EDs.