Hamilton Morris on 5-MeO-DMT, the Entourage Effect, and Protecting Toads
Morris has insightful ideas for studying psychedelic toad secretions while prioritizing the conservation of toads.
Scientific Research - Page 18
Habitat Influences Psychoactive Toad Secretions
Environment and diet may play a role in the alkaloid content of secretions from a Brazilian toad species.
New Biosynthesis of Psilocybin and Related Tryptamines
Researchers took the psilocybin-making genes from P. cubensis and put them into S. cerevisiae allowing them to produce psilocybin, several of its analogs, and a “new to nature” compound.
Psilocybin Superior to Ketamine for Prolonged Antidepressant-Like Effects (Rodent Model)
Results support the idea that serotonin 5-HT2A receptor-directed therapeutic strategies may be superior to ketamine-based treatments for depression.
Kratom Compound Mitragynine Reduces Neuropathic Pain, Study Finds
Pain was inhibited by an α2-adrenoceptor antagonist and reduced by an α1-adrenoceptor antagonist. Opioid receptors may also be involved in the effects.
Psilocybin Mindfulness Negatively Correlated with 5-HT2A Binding, Study Finds
Results hint at a possible mechanism for the persistent effect that psilocybin has on mindfulness.
Study Shows Norpsilocin is More Potent Than Psilocin at 5-HT2A
Greater potency means doing more with less. But does norpsilocin even have a role in the psychedelic effect?
Scientists Solve Another Crystal Structure of the Psilocybin Analog Miprocin, 4-HO-MiPT
This is the second crystal structure of this compound, providing additional options for developing psychedelics into therapeutic drug formulations.
5 Fast Facts You May Not Know About Albert Hofmann and LSD
Hofmann’s work with LSD started with purpose, faded away, and then went down in history.
Study Indicates the Magic Mushroom Compound Baeocystin is Not Psychedelic
Baeocystin does not cause the head twitch in mice, but its metabolite norpsilocin is more potent than psilocin.