Beneficial Synergy: Teaming Psilocybin with Mindfulness Meditation

A double-blind study reveals that mindfulness meditation practice may amplify the positive effects of psilocybin while reducing the likelihood of a bad trip.


Set and setting are both acknowledged to shape one’s experience of psychedelic medicine profoundly.1 Set refers to an individual’s expectation of the experience, their personality, and current mood. Setting, on the other hand, speaks to the physical and social environment in which the experience takes place.

Armed with this knowledge, a team of researchers recently set out to explore the effects of a 5-day mindfulness meditation retreat combined with a psychedelic experience.2 The double-blinded placebo-controlled study, which was published in the October 2019 issue of Nature Scientific Reports, revealed some fascinating findings.

Meditation and Psilocybin: Parallel Pathways to Self-Dissolution?

Throughout history, both meditation and psilocybin have offered gateways to self-transcendence, non-dual awareness, mystical awareness, and personal change.3 Both meditation and psychedelic experiences offer the potential for beneficial therapeutic outcomes, such as prosocial behavior and the alleviation of depression, stress, and anxiety.4 Despite the similarities that both meditation and psychedelics may induce in one’s sense of self, these two experiences have never been systematically investigated.

While psychedelic experiences that induce self-dissolution occur at relatively high rates (up to 60 percent),5 profound states of selflessness occur more infrequently during meditation and are usually confined to long-term meditators.6 However, the self-dissolution induced by psychedelic experience can also be accompanied by severe anxiety and a groundswell of emotion. Smigielski et al. hypothesized that a mindfulness meditation practice teamed with psychedelic experience could lead to greater changes than mindfulness meditation alone and reduce the likelihood of ‘a bad trip.’ 

Mindfulness meditation represents a specific type of meditation.7 Simply put, it is “nonjudgemental attention to present-moment experiences.” Smigielski et al. describe it as “a temporary state of intentional self-regulation of attention to foster greater awareness of one’s sensations, emotions, and thoughts with a non-judgmental attitude.” 2

The Study

Thirty-nine expert Buddhist meditation practitioners were recruited for a five-day mindfulness meditation retreat. Two-thirds of the participants had never experienced psychedelics before, and one-third had experienced limited previous exposure. On the fourth day of the retreat, 19 participants received a placebo capsule, and 20 received a psilocybin capsule in a double-blind manner. The psilocybin dose within the capsule was calculated based on the individual’s weight and contained 315 micrograms of psilocybin per kilogram of body weight.

The researchers evaluated the spectrum and extent of change in consciousness, the loss of cognitive control and anxiety, and the level of mystical-type experience using a range of tools. These tools included the Freiburg Mindfulness Inventory, the Meditation Depth Questionnaire, the Toronto Mindfulness Scale, the 5-Dimensional Altered States of Consciousness rating scale (5D-ASC) which is designed to quantify both positive and negative forms of ego dissolution, and the M-scale which assesses external and internal aspects of mystical experience. 

After four months had elapsed, participants completed the Life Changes Inventory, Revised (LCI-R) questionnaire, which evaluates changes in attitudes and behaviors. Each participant additionally designated a closely-related person to complete a third-person LCI-R questionnaire concerning the participant. Finally, the researchers asked the participants how personally meaningful the experience was, and whether they had perceived any enduring changes in their behavior or attitudes in themselves.

The Findings

The outcome of the research offers some compelling findings. The combination of psilocybin and mindfulness meditation produced markedly more pronounced alterations of consciousness than mindfulness meditation alone. The alterations that were more profoundly experienced included a sense of unity, spiritual experience, blissfulness, insightfulness, disembodiment, complex imagery, audiovisual synesthesia, and changed meanings of precepts.

Those who received the psilocybin capsule also noted a deeper sense of self-dissolution than those who received the placebo. Nineteen out of the 20 participants who received psilocybin met the criteria for having had an intense mystical experience, compared with 3 out of 10 participants in the placebo group. While the depth of mindfulness meditation increased throughout the retreat, the participants who received psilocybin were able to deepen their mindfulness meditation practice significantly. Ultimately, the evidence suggests that incorporating mindfulness meditation into psychedelic experiences may positively shape the experience. 

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Critically, the study also demonstrated that mindfulness meditation teamed with psilocybin bolstered the non-judgmental acceptance of thoughts and emotions and emotional regulation. Participants experienced virtually no loss of cognitive control or anxiety, despite the relatively high dose of psilocybin used, and also reported a positive self-dissolution experience. These findings support the hypothesis that mindfulness meditation may buffer psilocybin-induced anxiety and vigilance deficits. In other words, the addition of mindfulness meditation appeared to reduce the likelihood of having a ‘bad trip.’

Four Months Later: What Were the Lasting Effects of the Experience?

Four months after the retreat, researchers followed up with the participants to evaluate whether the experience had imprinted lasting behavioral or attitudinal changes. Those who had received the psilocybin scored significantly higher on a scale of appreciation for life, self-acceptance, quest for meaning, sense of purpose, and appreciation of death. The individuals who had received psilocybin also scored higher on scales for concern for others and spirituality but scored lower with respect to concern about worldly achievements. 

The psilocybin group additionally ascribed significant personal meaning to the experience four months later. Thirty-seven percent considered it one of the five most meaningful experiences in their lives, while 47 percent considered it in their top ten. Other literature has indicated that enduring positive changes in attitude and behavior following one or two doses of psilocybin have been reported to persist for 14 months or longer.8 It’s also noteworthy that although the group had expressed high life satisfaction before the study, they still notably benefited from the experience.

The Bottom Line

Going forward, this study by Smigielski et al. suggests that mindfulness meditation could potentially be integrated into psychedelic experiences as a powerful tool for transformation. Mindfulness meditation has already been linked to a range of formative health and well-being markers.9 

The authors indicate that a combination of mindfulness meditation with psychedelic-assisted intervention could be used to improve well-being in both therapeutic and non-therapeutic settings. Most critically, the synergy of mindfulness meditation practice with psychedelic-assisted intervention may provide a more therapeutically beneficial experience than psychedelics alone.


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Daniel Mulford
3 years ago

Sorry, but the language in both the article and the original study are misleading. The independent variable in the experiment is psilocybin, not meditation. The “bottom line” is not that “mindfulness meditation could potentially be integrated into psychedelic experiences as a powerful tool for transformation”. The bottom line is that people who claim to be expert meditators get high when you give them psilocybin. Big surprise.

3 years ago
Reply to  Daniel Mulford

And then they stay high for 4 months 0.O

3 years ago
Reply to  Jacob

I think the better way to put it would’ve been to ask whether meditation helps you have a better trip and maintain the benefits for longer compared to people who take psilocybin without meditating. I don’t like how they phrase it as the opposite.

3 years ago

Super interesting article! The quality of the research is apparent with an appropriate control group and nice sample size. It’s nice to read research on meditation that is straightforward and reproducible. And in conjunction with reputable plant medicine, well done! Thanks for covering.

3 years ago

could it help with alcolic!!c addidition?

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