New Biosynthesis of Psilocybin and Related Tryptamines
Researchers took the psilocybin-making genes from P. cubensis and put them into S. cerevisiae allowing them to produce psilocybin, several of its analogs, and a “new to nature” compound.
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Psilocybin Superior to Ketamine for Prolonged Antidepressant-Like Effects (Rodent Model)
Results support the idea that serotonin 5-HT2A receptor-directed therapeutic strategies may be superior to ketamine-based treatments for depression.
Kratom Compound Mitragynine Reduces Neuropathic Pain, Study Finds
Pain was inhibited by an α2-adrenoceptor antagonist and reduced by an α1-adrenoceptor antagonist. Opioid receptors may also be involved in the effects.
Comparing Aeruginascin and Bufotenidine
Although aeruginascin is only present in psilocybin mushrooms and bufotenidine is present in toads, their structural and chemical similarities may be surprising.
G Protein-Coupled Receptors: What Are They and How Do They Work?
GPCRs play a major role in the psychedelic effect. They also have qualities that make them ideal targets for drug development.
Understanding Drug Potency and Its Importance in Psychedelic Research
Understanding the potency of the compounds in nature’s cocktails is essential for formulating effective doses.
The Structure and Function of the Serotonin 5-HT2B Receptor
Severe side effects associated with 5-HT2B agonist drugs have dampened the interest of researchers. The therapeutic potential of psychedelics provides incentive for taking it up again.
Psilocybin Mindfulness Negatively Correlated with 5-HT2A Binding, Study Finds
Results hint at a possible mechanism for the persistent effect that psilocybin has on mindfulness.
Cellular Receptors and Their Role in the Psychedelic Effect
Research is revealing that the psychedelic effect is due to much more than 5-HT2A activation.
Study Shows Norpsilocin is More Potent Than Psilocin at 5-HT2A
Greater potency means doing more with less. But does norpsilocin even have a role in the psychedelic effect?