4-OH-TMT is the putative metabolic product of the magic mushroom compound aeruginascin.1 It is also an analog of the most well-known magic mushroom compound, psilocybin.

The Chemistry of 4-OH-TMT

4-OH-DMT is aeruginascin without the phosphate group on carbon 4. According to a 2006 study by Jensen et al., 4-OH-DMT gave an immediate gray color with Ehrlich’s reagent compared to aeruginascin which was purple.1 In their thin-layer chromatography (TLC) tests, the researchers also found that 4-OH-TMT had an Rf of 0.62 using a n-PrOH/NH3 28% eluent.

The Pharmacology of 4-OH-TMT

There is no research on the pharmacology of 4-OH-TMT. Following the similar chemical structure and metabolism of compounds like psilocybin and baeocystin, one could conclude that 4-OH-TMT is the metabolically dephosphorylated version of aeruginascin.

The Applications and Potential of 4-OH-TMT

Studying 4-OH-TMT is a wide-open area of psychedelic drug research.

  1. Jensen N, Gartz J, Laatsch H. Aeruginascin, a trimethylammonium analogue of psilocybin from the hallucinogenic mushroom Inocybe aeruginascens. Planta Medica. 2006;72(7):665. doi:10.1055/s-2006-931576